abstract：:Amphiphilic polymers are particularly useful for drug delivery because of their ability to self-assemble into discrete aggregates. While this behavior has been studied in depth for simple linear block copolymer amphiphiles, recent advances in synthetic methodologies have provided efficient routes to amphiphilic polyme...

journal_title：Advanced drug delivery reviews

authors： Wang Y,Grayson SM

更新日期：2012-06-15 00:00:00

abstract：:Recent pre-clinical and clinical studies have shown that stem cell-based therapies hold tremendous promise for the treatment of human disease. Mesenchymal stem cells (MSC) are emerging as promising anti-cancer agents which have an enormous potential to be utilized to treat a number of different cancer types. MSC have ...

journal_title：Advanced drug delivery reviews

authors： Shah K

更新日期：2012-06-01 00:00:00

abstract：:The blood-brain barrier (BBB) is a highly regulated and efficient barrier that provides a sanctuary to the brain. It is designed to regulate brain homeostasis and to permit selective transport of molecules that are essential for brain function. Unfortunately, drug transport to the brain is hampered by this almost impe...

journal_title：Advanced drug delivery reviews

authors： Chen Y,Liu L

更新日期：2012-05-15 00:00:00

abstract：:During the past few decades, the novel biotherapeutic agents such as peptides and proteins have been contributed to the treatment of several diseases. However, their oral absorption is significantly limited due to their poor delivery through the intestinal mucosa. Therefore, the feasible approaches are needed for impr...

journal_title：Advanced drug delivery reviews

authors： Khafagy el-S,Morishita M

更新日期：2012-05-01 00:00:00

abstract：:Oral delivery is the most common method for drug administration. However, poor solubility, stability, and bioavailability of many drugs make achieving therapeutic levels via the gastrointestinal (GI) tract challenging. Drug delivery must overcome numerous hurdles, including the acidic gastric environment and the conti...

journal_title：Advanced drug delivery reviews

authors： Ensign LM,Cone R,Hanes J

更新日期：2012-05-01 00:00:00

abstract：:Micro-/nanoscale technologies such as lithographic techniques and microfluidics offer promising avenues to revolutionalize the fields of tissue engineering, drug discovery, diagnostics and personalized medicine. Microfabrication techniques are being explored for drug delivery applications due to their ability to combi...

journal_title：Advanced drug delivery reviews

authors： Sant S,Tao SL,Fisher OZ,Xu Q,Peppas NA,Khademhosseini A

更新日期：2012-05-01 00:00:00

abstract：:Computational Fluid Dynamics (CFD) and Discrete Element Modelling (DEM) studies relevant to inhaled drug delivery are reviewed. CFD is widely used in device design to determine airflow patterns and turbulence levels. CFD is also used to simulate particles and droplets, which are subjected to various forces, turbulence...

journal_title：Advanced drug delivery reviews

authors： Wong W,Fletcher DF,Traini D,Chan HK,Young PM

更新日期：2012-03-30 00:00:00

abstract：:While nanotechnology and the production of nanoparticles are growing exponentially, research into the toxicological impact and possible hazard of nanoparticles to human health and the environment is still in its infancy. This review aims to give a comprehensive summary of what is known today about nanoparticle toxicol...

journal_title：Advanced drug delivery reviews

authors： Elsaesser A,Howard CV

更新日期：2012-02-01 00:00:00

abstract：:Small interfering RNA (siRNA) has a huge potential for the treatment or prevention of various lung diseases. Once the RNA molecules have successfully entered the target cells, they could inhibit the expression of specific gene sequence through RNA interference (RNAi) mechanism and generate therapeutic effects. The big...

journal_title：Advanced drug delivery reviews

authors： Lam JK,Liang W,Chan HK

更新日期：2012-01-01 00:00:00

abstract：:Drug-device combination products introduced a new dynamic on medical product development, regulatory approval, and corporate interaction that provide valuable lessons for the development of new generations of combination products. This paper examines the case studies of drug-eluting stents and transdermal patches to f...

journal_title：Advanced drug delivery reviews

authors： Couto DS,Perez-Breva L,Saraiva P,Cooney CL

更新日期：2012-01-01 00:00:00

abstract：:When an artificial biomaterial (e.g., a stent or implantable pump) is exposed to blood, plasma proteins immediately adhere to the surface, creating a new interface between the biomaterial and the blood. The recognition proteins within the complement and contact activation/coagulation cascade systems of the blood will ...

journal_title：Advanced drug delivery reviews

authors： Ekdahl KN,Lambris JD,Elwing H,Ricklin D,Nilsson PH,Teramura Y,Nicholls IA,Nilsson B

更新日期：2011-09-16 00:00:00

abstract：:As the mainstay in the treatment of various cancers for several decades, chemotherapy is successful but still faces challenges including non-selectivity and high toxicity. Improving the selectivity is therefore a critical step to improve the therapeutic efficacy of chemotherapy. Prodrug is one of the most promising ap...

journal_title：Advanced drug delivery reviews

authors： Mahato R,Tai W,Cheng K

更新日期：2011-07-18 00:00:00

abstract：:A "microdose clinical trial" (microdosing) is one kind of early phase exploratory clinical trial, administering the compound at doses estimated to have no pharmacological or toxicological effects, aimed at screening candidates for further clinical development. This article's objective is to clarify the ethical, legal,...

journal_title：Advanced drug delivery reviews

authors： Kurihara C

更新日期：2011-06-19 00:00:00

abstract：:The microdose (MD) clinical study enables to select a "better" compound for new drug candidate that shows desirable PK profiles in human. This new methodology is highly expected to streamline the drug development and to increase the success probability in the clinical trial. Since only a small amount of the test compo...

journal_title：Advanced drug delivery reviews

authors： Sugiyama Y,Yamashita S

更新日期：2011-06-19 00:00:00

abstract：:A significant percentage of active pharmaceutical ingredients identified through discovery screening programs is poorly soluble in water. These molecules are often difficult to formulate using conventional approaches and are associated with innumerable formulation-related performance issues, e.g. poor bioavailability,...

journal_title：Advanced drug delivery reviews

authors： Merisko-Liversidge E,Liversidge GG

更新日期：2011-05-30 00:00:00

abstract：:Tissue engineering aims to provide structural and biomolecular cues to compromised tissues through scaffolds. An emerging biomolecular cue is that of RNA interference by which the expression of genes can be silenced through a potent endogenous pathway. Recombinant viral-based approaches in RNAi delivery exist; however...

journal_title：Advanced drug delivery reviews

authors： Monaghan M,Pandit A

更新日期：2011-04-30 00:00:00

abstract：:Islet transplantation has the potential to cure type 1 diabetes. Despite recent therapeutic success, it is still not common because a large number of transplanted islets get damaged by multiple challenges including instant blood mediated inflammatory reaction, hypoxia/reperfusion injury, inflammatory cytokines, and im...

journal_title：Advanced drug delivery reviews

authors： Li F,Mahato RI

更新日期：2011-01-01 00:00:00

abstract：:Injury to the podocytes is the initiating cause of many renal diseases, leading to proteinuria with possible progression to end-stage renal disease. Podocytes are highly specialized cells, with an important role in maintaining the glomerular filtration barrier and producing growth factors for both mesangial cells and ...

journal_title：Advanced drug delivery reviews

authors： Leeuwis JW,Nguyen TQ,Dendooven A,Kok RJ,Goldschmeding R

更新日期：2010-11-30 00:00:00

abstract：:Drug resistance involves multiple mechanisms. Multidrug resistance (MDR) is the leading cause of treatment failure in cancer therapy. Elevated levels of MDR proteins [members of the ATP-binding cassette (ABC) transporter family] increase cellular efflux and decrease the effectiveness of chemotherapeutic agents. As a s...

journal_title：Advanced drug delivery reviews

authors： Chen T

更新日期：2010-10-30 00:00:00

abstract：:Estrogens regulate growth and development through the action of two distinct estrogen receptors (ERs), ERα and ERβ, which mediate proliferation and differentiation of cells. For decades, ERα mediated estrogen signaling has been therapeutically targeted to treat breast cancer, most notably with the selective estrogen r...

journal_title：Advanced drug delivery reviews

authors： Shanle EK,Xu W

更新日期：2010-10-30 00:00:00

abstract：:Mesenchymal stem cells (MSC) are a promising tool for cell therapy, either through direct contribution to the repair of bone, tendon and cartilage or as an adjunct therapy through protein production and immune mediation. They are an attractive vehicle for cellular therapies due to a variety of cell intrinsic and envir...

journal_title：Advanced drug delivery reviews

authors： Meyerrose T,Olson S,Pontow S,Kalomoiris S,Jung Y,Annett G,Bauer G,Nolta JA

更新日期：2010-09-30 00:00:00

abstract：:Molecular imaging is an emerging technology that allows the visualization of interactions between molecular probes and biological targets. Molecules that either direct or are subject to homeostatic controls in biological systems could be labeled with the appropriate radioisotopes for the quantitative measurement of se...

journal_title：Advanced drug delivery reviews

authors： Li Z,Conti PS

更新日期：2010-08-30 00:00:00

abstract：:Theranostics, the fusion of therapy and diagnostics for optimizing efficacy and safety of therapeutic regimes, is a growing field that is paving the way towards the goal of personalized medicine for the benefit of patients. The use of light as a remote-activation mechanism for drug delivery has received increased atte...

journal_title：Advanced drug delivery reviews

authors： Rai P,Mallidi S,Zheng X,Rahmanzadeh R,Mir Y,Elrington S,Khurshid A,Hasan T

更新日期：2010-08-30 00:00:00

abstract：:Cardiovascular functions such as heart rate and blood pressure show 24h variation. The incidence of cardiovascular diseases including acute myocardial infarction and arrhythmia also exhibits diurnal variation. The center of this circadian clock is located in the suprachiasmatic nucleus in the hypothalamus. However, re...

journal_title：Advanced drug delivery reviews

authors： Takeda N,Maemura K

更新日期：2010-07-31 00:00:00

abstract：:The biological clock of mammals is under the control of external factors, social life and the environment, and of internal genetic factors. When the biological clock of an individual is no longer in phase with its environment, either because there is no longer any harmony (desynchronization) between the two systems (s...

journal_title：Advanced drug delivery reviews

authors： Touitou Y,Coste O,Dispersyn G,Pain L

更新日期：2010-07-31 00:00:00

abstract：:Hydrogels are synthetic or natural polymer networks that closely mimic native extracellular matrices. As hydrogel-based vehicles are being increasingly employed in therapeutic cell delivery, two inherent traits of most common hydrogels, namely low cell affinity and high cell constraint, have significantly drawn the at...

journal_title：Advanced drug delivery reviews

authors： Wang C,Varshney RR,Wang DA

更新日期：2010-06-15 00:00:00

abstract：:Endogenous regenerative technology (Endoret) involves the use of patient's own biologically active proteins, growth factors and biomaterial scaffolds for therapeutic purposes. This technology provides a new approach for the stimulation and acceleration of tissue healing and bone regeneration. The versatility and bioco...

journal_title：Advanced drug delivery reviews

authors： Anitua E,Sánchez M,Orive G

更新日期：2010-06-15 00:00:00

abstract：:Infectious diseases are prevalent in the developing world and are one of the developing world's major sources of morbidity and mortality. While infectious diseases can initiate in a localized region, they can spread rapidly at any moment due to the ease of traveling from one part of the world to the next. This could l...

journal_title：Advanced drug delivery reviews

authors： Hauck TS,Giri S,Gao Y,Chan WC

更新日期：2010-03-18 00:00:00

abstract：:There is an urgent need for new strategies to combat infectious diseases in developing countries. Many pathogens have evolved to elude immunity and this has limited the utility of current therapies. Additionally, the emergence of co-infections and drug resistant pathogens has increased the need for advanced therapeuti...

journal_title：Advanced drug delivery reviews

authors： Look M,Bandyopadhyay A,Blum JS,Fahmy TM

更新日期：2010-03-18 00:00:00

abstract：:Over several thousand years, the flagellated Trypanosome cruzi-causative agent of Chagas disease-developed a complex life cycle between the reduviidae vectors and its human hosts. Due to their silent and hidden location, the intracellular amastigotes are mainly responsible for the nearly 50,000 annual deaths caused by...

journal_title：Advanced drug delivery reviews

authors： Romero EL,Morilla MJ

更新日期：2010-03-18 00:00:00

abstract：:Among non-viral vectors, chitosan and chitosan derivatives have been developed in vitro and in vivo for DNA and siRNA delivery systems because of their cationic charge, biodegradability and biocompatibility, as well as their mucoadhesive and permeability-enhancing properties. However, the transfection efficiency of ch...

journal_title：Advanced drug delivery reviews

authors： Mao S,Sun W,Kissel T

更新日期：2010-01-31 00:00:00

abstract：:Mitochondria represent both the main source and target of reactive oxygen and nitrogen species (RONS). In view of the large energy expenditure made by neurons during neurotransmission, an intact mitochondrial function is of paramount importance for the correct function of the brain. Accordingly, the search of therapeu...

journal_title：Advanced drug delivery reviews

authors： Bolaños JP,Moro MA,Lizasoain I,Almeida A

更新日期：2009-11-30 00:00:00

abstract：:Endogenous acetylcarnitine is an indicator of acetyl-CoA synthesized by multiple metabolic pathways involving carbohydrates, amino acids, fatty acids, sterols, and ketone bodies, and utilized mainly by the tricarboxylic acid cycle. Acetylcarnitine supplementation has beneficial effects in elderly animals and humans, i...

journal_title：Advanced drug delivery reviews

authors： Rosca MG,Lemieux H,Hoppel CL

更新日期：2009-11-30 00:00:00

abstract：:Cancer treatment regimens often include multiple anticancer agents targeting different cellular mechanisms in delicate balance with associated toxicity. Drug delivery systems offer a unique tool in the treatment of cancer, and applications in the local treatment of cancer have demonstrated utility in providing sustain...

journal_title：Advanced drug delivery reviews

authors： Elstad NL,Fowers KD

更新日期：2009-08-10 00:00:00

abstract：:Transcriptional targeting using a mammalian cellular promoter to restrict transgene expression to target cells is often desirable for gene therapy. This strategy is, however, hindered by relatively weak activity of some cellular promoters, which may lead to low levels of gene expression, thus declining therapeutic eff...

journal_title：Advanced drug delivery reviews

authors： Boulaire J,Balani P,Wang S

更新日期：2009-07-02 00:00:00

abstract：:Despite recent progress in our knowledge about the development and therapy of colorectal cancer (CRC), it still remains one of the major cancer related deaths throughout the world. With the introduction of new cytotoxic and targeting agents a significant improvement in progression-free and overall survival has been ac...

journal_title：Advanced drug delivery reviews

authors： Pohl A,Lurje G,Manegold PC,Lenz HJ

更新日期：2009-05-20 00:00:00

abstract：:Thioredoxin 1 (Trx 1) is a redox-active small protein ubiquitously present in human body. It is one of the defensive proteins induced in response to various stress conditions. In addition to its anti-oxidative effect by dithiol-disulfide exchange in its active site, Trx 1 has anti-apoptotic and anti-inflammatory effec...

journal_title：Advanced drug delivery reviews

authors： Nakamura H,Hoshino Y,Okuyama H,Matsuo Y,Yodoi J

更新日期：2009-04-28 00:00:00

abstract：:Toll-like receptor 9 (TLR9) agonists have demonstrated substantial potential as vaccine adjuvants, and as mono- or combination therapies for the treatment of cancer and infectious and allergic diseases. Commonly referred to as CpG oligodeoxynucleotides (ODN), TLR9 agonists directly induce the activation and maturation...

journal_title：Advanced drug delivery reviews

authors： Vollmer J,Krieg AM

更新日期：2009-03-28 00:00:00

abstract：:The great interest in mucosal vaccine delivery arises from the fact that mucosal surfaces represent the major site of entry for many pathogens. Among other mucosal sites, nasal delivery is especially attractive for immunization, as the nasal epithelium is characterized by relatively high permeability, low enzymatic ac...

journal_title：Advanced drug delivery reviews

authors： Csaba N,Garcia-Fuentes M,Alonso MJ

更新日期：2009-02-27 00:00:00

abstract：:Many inner ear disorders cannot be adequately treated by systemic drug delivery. A blood-cochlear barrier exists, similar physiologically to the blood-brain barrier, which limits the concentration and size of molecules able to leave the circulation and gain access to the cells of the inner ear. However, research in no...

journal_title：Advanced drug delivery reviews

authors： Swan EE,Mescher MJ,Sewell WF,Tao SL,Borenstein JT

更新日期：2008-12-14 00:00:00